Campus WelsTechnik & Angewandte Naturwissenschaften

Publications

2017

Journals

R. Wagner, G. Stübiger, D. Veigel, M. Wuczkowski, P. Lanzerstorfer, J. Weghuber, E. Karteris, K. Nowikovsky, N. Wilfinger, C.F. Singer, R. Colomer, B. Benhamu, M.L. Lopez-Rodriguez, P. Valent, T.W. Grunt. Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells. Oncotarget. In press.

Schütz GJ, Weghuber J, Lanzerstorfer P, Sevcsik E. Protein Micropatterning Assay: Quantitative Analysis of Protein-Protein Interactions. Methods Mol. Biol. 2017;1550:261-270.

2016

Journals

Barbara Hohensinn, Renate Haselgrübler, Ulrike Müller, Verena Stadlbauer, Peter Lanzerstorfer, Gerald Lirk, Otmar Höglinger, Julian Weghuber. (2016) Sustaining elevated levels of nitrite in the oral cavity through consumption of nitrate-rich beetroot juice in young healthy adults reduces salivary pH. Nitric Oxide. 60:10-15.

Florian Baumgart, Andreas Arnold, Konrad Leskovar, Kaj Staszek, Martin Fölser, Julian Weghuber, Hannes Stockinger, Gerhard J Schütz. (2016) Label density variation to probe membrane protein nanoclusters in dSTORM/PALM. Nature Methods. Aug;13(8):661-4.

Verena Stadlbauer, Renate Haselgrübler, Peter Lanzerstorfer, Birgit Plochberger, Daniela Borgmann, Jaroslaw Jacak, Stephan M Winkler, Klaus Schröder, Otmar Höglinger, Julian Weghuber. (2016) Biomolecular Characterization of Putative Antidiabetic Herbal Extracts. PLoS ONE 11(1):e0148109.

Conferences

P. Lanzerstorfer, Y. Yoneyama, U. Müller, R. Haselgrübler, D. Zindel, O. Höglinger, F. Hakuno, C. Krasel, S. Takahashi, M. Bünemann, J. Weghuber. Analysis of receptor tyrosine kinase and G-protein coupled receptor signaling dynamics on micro-structured surfaces. Biophysical Journal, Vol. 110, No. 3, 2016.

R. Wagner, G. Stübiger, P. Lanzerstorfer, J. Weghuber, E. Karteris, K. Nowikovsky, N. Wilfinger, R. Colomer, M. Regueiro Rodríguez, T. Grunt. Exploiting cross-talk between lipid metabolism and oncogenic signaling for treatment of ovarian cancer - EUROPEAN JOURNAL OF CANCER, Vol. 61, No. 1, 2016, pp. 61

2015

Journals

Eva Sevcsik, Mario Brameshuber, Martin Fölser, Julian Weghuber, Alf Honigmann and Gerhard J. Schütz (2015). GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane. Nature Communications. 6:6969.

Jürgen Wruss, Gundula Waldenberger, Stefan Huemer, Pinar Uygun, Peter Lanzerstorfer, Ulrike Müller, Otmar Höglinger and Julian Weghuber (2015). Compositional characteristics of commercial beetroot products and beetroot juice prepared from seven beetroot varieties grown in Uper Austria. Journal of Food Composition and Analysis. 42:46-55.

Jürgen Wruss, Peter Lanzerstorfer, Stefan Huemer, Markus Himmelsbach, Harald Mangge, Otmar Höglinger, Daniel Weghuber and Julian Weghuber (2015). Differences in pharmacokinetics of apple polyphenols after standardized oral consumption of unprocessed apple juice. Nutritional Journal. 14(32).

Peter Lanzerstorfer, Yosuke Yoneyama, Fumihiko Hakuno, Ulrike Müller, Otmar Höglinger, Shin-Ichiro Takahashi and Julian Weghuber (2015). Analysis of insulin receptor substrate (IRS) signaling dynamics on micro-structured surfaces. FEBS Journal. 282(6).

Diana Zindel, Adrian J Butcher, Suleiman Al-Sabah, Peter Lanzerstorfer, Julian Weghuber, Andrew B Tobin, Moritz Bünemann, Cornelius Krasel. (2015). Engineered Hyperphosphorylation of the β2-adrenoceptor Prolongs Arrestin-3 Binding and Induces Arrestin Internalization. Molecular Pharmacology. 87(2):349-62.

Conferences

Peter Lanzerstorfer, Ulrike Müller, Diana Zindel, Otmar Höglinger, Cornelius Krasel, Moritz Bünemann and Julian Weghuber (2015). Localization and dynamics of beta-adrenergic receptor mediated EGFR transactivation on micro-patterned surfaces. Biophysical Journal. 108(2). p95a.

Ulrike Müller, Peter Lanzerstorfer, Andreas Arnold, Eva Sevcsik, Gerald Kreindl, Otmar Höglinger, Gerhard J. Schütz and Julian Weghuber (2015). Novel strategies for micro-contact printing based protein-protein interaction detection. Biophysical Journal. 108(2). p480a-481a.

2014

Journals

P. Lanzerstorfer,V. Stadlbauer, L. Chtcheglova, R. Haselgrübler, D.M. Borgmann, J. Wruss, P. Hinterdorfer, K. Schröder, S.M. Winkler, O. Höglinger, J. Weghuber. (2014). Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (TIRF) microscopy. British Journal of Pharmacology. 171(23). pp 5237-5251.

P Lanzerstorfer, D Borgmann, G Schütz, SM Winkler, O Höglinger, J Weghuber. (2014). Quantification and Kinetic Analysis of Grb2-EGFR Interaction on Micro-Patterned Surfaces for the Characterization of EGFR-Modulating Substances. PLoS ONE 9(3).

Lanzerstorfer P., Wruss J., Huemer S., Steininger A., Müller U., Himmelsbacher M., Borgmann D., Winkler S., Höglinger O., Weghuber J. (2014). Bioanalytical characterization of apple juice from 88 grafted and nongrafted apple varieties grown in Upper Austria. J Agric Food Chem. 62 (5). pp 1047-1056.

Conferences

V. Stadlbauer, P. Lanzerstorfer, D. M. Borgmann, J. Wruss, K. Schröder, S. M. Winkler, O. Höglinger, J. Weghuber - Total Internal Reflection Fluorescence (TIRF) Microscopy Guided Quantification of GLUT4 Translocation for the Identification of Insulin Mimetic Drugs - BIOPHYSICAL JOURNAL, Vol. 106, No. 2, 2014.

P. Lanzerstorfer, S. Takahashi, O. Höglinger, J. Wruss - A Live Cell Tirf-Microscopy Based Screening Assay for Fast Analysis of Receptor Tyrosine Kinase Modulators - BIOPHYSICAL JOURNAL, Vol. 106, No. 2, 2014.

U. Müller, P. Lanzerstorfer, A. Arnold, E. Sevcsik, G. Kreindl, O. Höglinger, G. Schütz, J. Weghuber - Characterization of various pattern designs for micro-contact printing based protein-protein interaction detection - Annual Meeting of the German Biophysical Society (DGfB), Lübeck, Deutschland, 2014.

P. Lanzerstorfer - Tyrosine kinase receptor signaling dynamics studied with micropatterned surfaces, Annual Meeting of the German Biophysical Society (DGfB), Lübeck, Deutschland, 2014.

2013

Journals

Christine Schäfer, Klaus Rudolf Schröder, Otmar Höglinger, Sajjad Tollabimazraehno, Mohammad Reza Lornejad-Schäfer. (2013). Acetaminophen changes intestinal epithelial cell membrane properties, subsequently affecting absorbtion processes. Cellular Physiology and Biochemistry. 32:431-447

Conferences

Peter Lanzerstorfer, Cornelius Krasel, Otmar Höglinger, Julian Weghuber. Protein-protein interactions of the β-adrenergic receptor and kinetic analysis of intracellular binding partners via µ-patterned surfaces. 57th Annual Meeting Biophysical Society 02/13

Peter Lanzerstorfer, Andrea Steininger, Shin Ichiro Takahashi, Otmar Höglinger, Julian Weghuber. Studying protein-protein interactions of receptor tyrosine kinases on µ-patterned surfaces. 57th Annual Meeting Biophysical Society 02/13

Peter Lanzerstorfer, Andrea Steininger, Verena Stadlbauer, Daniela Borgmann, Stephan Winkler, Otmar Höglinger, Julian Weghuber. Biophysical and biochemical characterization of insulin-dependent cellular systems in response to secondary plant metabolites. FFH 2013

2012

Journals

P. Lanzerstorfer, D. Borgmann, A. Steininger, S. Schaller, M. Brameshuber, S. Sunzenauer, O. Hoeglinger, J. Weghuber.Analysis of Protein-Protein Interactions in Live Cells - The Micro-Patterning Approach. Basic Methods in Protein Purification and Analysis.   iConcept Press. ISBN: 978-14775550-5-7.

Stefan Sunzenauer, Verena Zojer, Mario Brameshuber, Andreas Tröls, Julian Weghuber, Hannes Stockinger, Gerhard J Schütz. Determination of binding curves via protein micropatterning in vitro and in living cells. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 11/2012

Conferences

Peter Lanzerstorfer, Cornelius Krasel, Otmar Höglinger, Moritz Bünemann, Julian Weghuber. Studying protein-protein interactions of beta-adrenergic receptors via µ-patterned surfaces. 4th ÖGMBT Meeting 2012 Graz.

Andrea Steininger, Peter Lanzerstorfer, Shin-Ichiro Takahashi, Otmar Höglinger, Julian Weghuber. Interaction properties of receptor tyrosine kinases studied on µ-patterned surfaces. 4th ÖGMBT Meeting 2012 Graz.

T. Weber, M. Veit, K.R. Wendler, J. Weghuber, O. Höglinger. Evaluation of ammonia reduction potential of saponin containing plant materials by measurement of urease inhibition. 11. BOKU-Symposium Tierernährung 2012 Wien.

Otmar Höglinger, Birgit Henning, Thomas Kampitsch, Michaela Kröppl, Peter Lanzerstorfer, Julian Weghuber. Analysis of compositional characteristics of apple varieties from Upper Austria. Lebensmittelchemikertage 2012 Linz.

Otmar Höglinger, Birgit Redl, Thomas Kampitsch, Michaela Kröppl, Peter Lanzerstorfer, Julian Weghuber. Biochemical characterization of 121 apple cultivars from Upper Austria. Presentation, 67th ALVA meeting, Vienna.

Peter Lanzerstorfer, Gbenga Olawale, Otmar Höglinger, Julian Weghuber. Studying molecular effects of plant polyphenols on plasma-membrane localized molecules. Presentation, 67th ALVA meeting Vienna.

Peter Lanzerstorfer, Stefan Sunzenauer, Mario Brameshuber, Gerhard J. Schütz,  Shin-Ichiro Takahashi, Moritz Bünemann, Otmar Höglinger, Julian Weghuber. Drug screening on signal transduction proteins via µ-patterned surfaces. Presentation, Biophysical society (56th annual meeting 2012 San Diego).

Peter Lanzerstorfer, Stefan Sunzenauer, Mario Brameshuber, Gerhard J. Schütz, Moritz Bünemann, Otmar Höglinger, Julian Weghuber. Multimerization studies of membrane receptors via µ-patterned surfaces. Poster presentation, Biophysical society (56th annual meeting 2012 San Diego)

2011

Conferences

Peter Lanzerstorfer, Stefan Sunzenauer, Gerhard J. Schütz, Moritz Bünemann, Shin-Ichiro Takahashi, Otmar Höglinger, Julian Weghuber. Drug screening on signal transduction proteins via µ-patterned surfaces. Invited presentation, EMBO Meeting 2011 Vienna.

Journals

Julian Weghuber, Michael C. Aichinger, Mario Brameshuber, Stefan Wieser, Verena Ruprecht, Birgit Plochberger, Josef Madl, Andreas Horner, Siegfried Reipert, Karl Lohner, Tamás Henics, Gerhard J. Schütz. Cationic amphipatic peptides accumulate sialylated proteins and lipids in the plasma-membrane of eukaryotic host cells. Biochimica et Biophysica Acta - Biomembranes.

2010

Journals

Julian Weghuber, Stefan Sunzenauer, Mario Brameshuber, Birgit Plochberger, Clemens Hesch, Gerhard J Schuetz. In-vivo detection of protein-protein interactions on micro-patterned surfaces. Journal of Visualized Experiments March 19: 37.

Julian Weghuber, Stefan Sunzenauer, Birgit Plochberger, Mario Brameshuber, Thomas Haselgrübler, Gerhard J Schütz.Temporal resolution of protein-protein interactions in the live-cell plasma membrane. Analytical and Bioanalytical Chemistry, 397: 8. 3339-47.

Julian Weghuber, Mario Brameshuber, Stefan Sunzenauer, Manuela Lehner, Christian Paar, Thomas Haselgrübler, Michaela Schwarzenbacher, Martin Kaltenbrunner, Clemens Hesch, Wolfgang Paster, Bettina Heise, Alois Sonnleitner, Hannes Stockinger, Gerhard J. Schütz. Detection of protein-protein interactions in the live cell plasma membrane by quantifying prey redistribution upon bait micropatterning. Methods in Enzymology, 472: 133-151.

2009

Journals

Mario Brameshuber, Michaela Schwarzenbacher, Martin Kaltenbrunner, Clemens Hesch, Wolfgang Paster, Julian Weghuber, Bettina Heise, Alois Sonnleitner, Hannes Stockinger, Gerhard J. Schutz. Reply to "Uncoupling diffusion and binding in FRAP experiments". Nature Methods, 6: 3. 183-184.

2008

Journals

Michaela Schwarzenbacher, Martin Kaltenbrunner, Mario Brameshuber, Clemens Hesch, Wolfgang Paster, Julian Weghuber, Bettina Heise, Alois Sonnleitner, Hannes Stockinger, Gerhard J. Schutz. Micropatterning for quantitative analysis of protein-protein interactions in living cells. Nature Methods, 5: 12. 1053-1060.